Actinomycin D and Growth Response of Chick Comb to Androgens
نویسندگان
چکیده
منابع مشابه
DNA-dependent synthesis of RNA is not implicated in growth response of chick comb to androgens.
Local application of actinomycin D does not detectably modify growth response of the chick comb to androgens. The mode of action of androgens on chick comb (a connective-tissue organ) appears to differ from their action on epithelial-tissue organs such as seminal vesicles and prostate.
متن کاملResponse of Chick's Comb to Naturally Occurring Androgens and Estrogens *
The fact that the growth of the chick's comb is accelerated by the administration of androgenic material has been demonstrated by Ruzicka,3 by Burrows, Byerly, and Evans,' and by Frank and Klempner.' Ruzicka painted the chick's comb with a 0.5 per cent solution of androsterone in oil each day for a period of several weeks and obtained large increases in comb area. He did not, however, study thi...
متن کاملThe Differential Sensitivity of Cultured Chick Mesodermal Cells to Actinomycin D
Cells were isolated from the somite mesoderm and from the unsegmented (presomite) mesoderm of early chick embryos and exposed to actinomycin D in single cell culture. Actinomycin D inhibited proliferation in cell cultures derived from the unsegmented mesoderm, although the same concentrations of this antibiotic did not inhibit cultures derived from the somite mesoderm. This differential sensiti...
متن کاملThe effects of actinomycin D on the early development of quail and chick embryos.
In agreement with previous work it has been found that treatment of chick embryos at an early stage of development with small concentrations of actinomycin D (20-40 x 10~ M) produces abnormalities of the brain, neural tube and somites but allows near normal development of heart and blood islands. Similar effects are produced on quail embryos by even smaller concentrations of actinomycin D (0-8-...
متن کاملResponse of yeast and mycelial phases of Histoplasma capsulatum to amphotericin B and actinomycin D.
The dimorphic fungus Histoplasma capsulatum exists in two phases: a unicellular yeast form at 37 C and a mycelium at 25 C. We have found that these two phases have selective drug susceptibilities. The mycelial form of H. capsulatum was much more susceptible to the polyene antibiotic amphotericin B than the yeast form; in contrast, the yeast form was more susceptible to the antibiotic actinomyci...
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ژورنال
عنوان ژورنال: Science
سال: 1966
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.152.3726.1283-a